What does this gene do? The FLG gene provides instructions for making a large protein called profilaggrin. This protein is found in the cells in the outermost layer of the skin and plays a key role in maintaining this effective skin barrier. Profilaggrin is cleaved to produce many copies called filaggrin protein, these are important in the structure of the epidermis. Hydration of the skin is maint ...[Read More]