What does this gene do?

This gene codes for a member of the glutathione peroxidase family, the enzyme, Glutathione Peroxidase 1 (GPX1). This enzyme is one of the most important antioxidant selenium-dependent enzymes in humans.

GPX1 enzyme is able to protect against stress that would damage cell membranes from oxygen, DNA and proteins. As with other detox enzymes it’s job is to turn harmful particles into water-soluble ones.

TA decreased GPX1 activity is linked to the development of atherosclerotic lesions in humans.

The risk T allele has substantial lower enzyme activity meaning a higher risk of damage to cells.

The CT genotype is seen in 26% of caucasians and 42% of Africans. The TT genotype seen between 4-6% in Europeans and Africans respectively.

Other genes that work together: MnSOD, GPX, CAT, EPHX1